Flow cytometry analysis showed that LncRNA AK03516 or SMDA5-AS1 knockdown significantly increased cisplatinum-induced apoptosis in HCC cells, while LncRNA RP11–17803.2, TPTEP1, IDH1-AS1 or LINC00341 knockdown notably inhibited, compared to control (Fig. 1c). This evidence concerns the gene TPTEP1 and hepatocellular carcinoma.