To further investigate the effects of TPTEP1 on HCC cell proliferation, tumorigenicity and invasion, TPTEP1 overexpression (LV-TPTEP1) and knockdown (ShRNA-TPTEP1) cell lines were established by lentiviral infection in QGY-7703 or MHCC97H cells. The gene discussed is TPTEP1; the disease is hepatocellular carcinoma.