Flow cytometry analysis showed that LncRNA AK03516 or SMDA5-AS1 knockdown significantly increased cisplatinum-induced apoptosis in HCC cells, while LncRNA RP11–17803.2, TPTEP1, IDH1-AS1 or LINC00341 knockdown notably inhibited, compared to control (Fig. 1c). Here, SYNE3 is linked to hepatocellular carcinoma.