EPHX2 and breast carcinoma: To elucidate whether EET metabolite levels, CYP epoxygenase overexpression or sEH downregulation are involved in regulating unique pathways associated with or independent from hormone-related signaling in the different breast cancer subtypes, we constructed a discovery set comprising of mRNA microarray profiles from 3 non-overlapping BC cohorts from the TCGA database [46–48].