As a transcription factor, FOXM1 has many target genes including KIF20A, CENPF, CCNB1, MYC, NIMA-related kinase 2, MMP2, MMP9, and S-phase kinase-associated protein 2 that are implicated in cancer initiation, progression, or drug resistance [3, 9, 49]. This evidence concerns the gene CCNB1 and cancer.