A notable gene that undergoes lengthening in both the frontal and temporal lobes of AD patients compared to the controls is BIN1. The BIN1 gene, whose protein is involved in synaptic vesicle endocytosis, showed 3’UTR lengthening in the temporal and frontal lobe samples but not in the whole brain sample, qualifying it as a localised APA change (Fig. 2d). The gene discussed is BIN1; the disease is Alzheimer disease.