MED12 and non-small cell lung carcinoma: To determine the biological role of MED12 in NSCLC, we knocked out endogenous MED12 in human lung adenocarcinoma cells PC9 and SPC-A1 using the CRISPR-Cas9 system and reconstitution of exogenous MED12 using Lentiviral system (Fig. 2a-d).