For GPCR ligands, the levels of LPA has been considered as a marker for ovarian cancer, and high circulating angiotensin II is associated with carcinogenesis, prognosis, and drug resistance in several malignancies, such as colorectal cancer, hepatocellular carcinoma, melanoma, ovarian cancer, and breast cancer [135,136,137,138,139,140,141]. The gene discussed is AGT; the disease is ovarian cancer.