Moreover, we suggest that the expression of Shh observed in this study in the advanced stages of human pancreatic primary tissue could potentially be a marker of the presence of an αSMA−/αSMA+ mixed population which expresses molecules associated with the cancer stem cell niche and with driving metastatic potential [16] in the pancreatic tumour microenvironment. The gene discussed is SHH; the disease is pancreatic neoplasm.