Furthermore, there was a strong correlation between vimentin (Supporting Figure A2), used as a marker of stromal content, and Shh expression in both the epithelial and stromal compartments (Figure 1f,g) supporting the idea of a possible contribution of Shh signalling to the stromal expansion in pancreatic cancer [5] and indicating Shh as a new possible target to reduce the stromal mass in this cancer. Here, SHH is linked to familial pancreatic carcinoma.