In addition, HOTAIR downregulation leads to the decreased expression of mesenchymal-like markers (vimentin, FN1, Snail, Twist and ZEB1) and increased expression of epithelial protein (E-cadherin) in OCSC cells, highlighting its main role of HOTAIR in the modulation of EMT features [48]. Here, HOTAIR is linked to oral cavity squamous cell carcinoma.