In the present study, the levels of sCD30 (TNFRSF8), sTNF-R1, gp130 (sIL-6Rß), IL-19, IL-26 and MMP-1 were increased in serum, saliva or GCF samples from subjects with moderate/severe periodontitis as compared to no/mild disease. Here, TNFRSF8 is linked to periodontitis.