TNFSF10 and neoplasm: The evidence for the involvement of the endogenous TRAIL/TRAIL-R system in tumor elimination came from animal studies using TRAIL−/− [36,79,80] or TRAIL-R−/− mice [81,82,83] or mice that were injected with TRAIL neutralizing antibodies [84,85,86] and mostly conclude to a protective role of the TRAIL/TRAIL-R system against cancer development (Table 2).