In the case of TRAIL, the overexpression of the decoy receptors TRAIL-R3 and TRAIL-R4 have been reported in some tumor types (including acute myeloid leukemia), where they might sequester TRAIL, but also form heteromers with TRAIL-R1 and TRAIL-R2, thereby preventing TRAIL-R1 and TRAIL-R2 activation and proper DISC formation [25,106]. This evidence concerns the gene TNFRSF10B and acute myeloid leukemia.