In the case of TRAIL, the overexpression of the decoy receptors TRAIL-R3 and TRAIL-R4 have been reported in some tumor types (including acute myeloid leukemia), where they might sequester TRAIL, but also form heteromers with TRAIL-R1 and TRAIL-R2, thereby preventing TRAIL-R1 and TRAIL-R2 activation and proper DISC formation [25,106]. The gene discussed is TNFSF10; the disease is acute myeloid leukemia.