In contrast, a human genetic disease, called autoimmune lymphoproliferative syndrome (ALPS), arises from mutation in the fas gene, in the fasl gene, or in genes encoding for effector proteins that are involved in Fas-induced cell death signalling, such as FADD (Fas-Associated protein with Death Domain) and caspases-8 or-10 [59]. Here, CASP8 is linked to autoimmune lymphoproliferative syndrome.