FAS and Autoimmunity: Indeed, Stranges et al. reported that: (i) loss of Fas expression in T cells, which is critical for autoreactive T cell death recognizing low affinity self-ags, lead to autoimmune symptoms development and (ii) the conditional deletion of Fas in DC is sufficient to cause systemic autoimmunity, which is mainly due to DC accumulation and increased ag presentation [67] (Figure 1).