An increase of the symptoms observed when inducing EAE [38,39,40], RA [41], or type I diabetes [41] in TRAIL or TRAIL-R deficient mice (demonstrated mainly by using the C57BL/6 TRAIL−/− mice, C57BL/6 TRAIL-R−/−, but also the BALB/c TRAIL−/− mice) when compared to their wild type counterpart clearly demonstrated the protective role of the TRAIL/TRAIL-R systems (Table 1). Here, TNFSF10 is linked to type 1 diabetes mellitus.