We found that HMG20A expression in islets is essential for metabolism/insulin secretion coupling via the coordinated regulation of key islet-enriched genes such as NEUROD, MAFA, and insulin, and that its depletion induces expression of genes such as PAX4 and REST implicated in β-cell de-differentiation as observed in T2DM islets [41]. The gene discussed is INS; the disease is type 2 diabetes mellitus.