In some cases, UPR induction is clearly linked with a malignant phenotype and aggressiveness, as shown by XBP1 overexpression in human multiple myeloma [83], and overactivation of PERK-ATF4 in MYC-induced lymphomas [79], breast cancers [84] and colorectal adenocarcinomas [85]. Here, EIF2AK3 is linked to breast carcinoma.