EIF2AK3 and lung adenocarcinoma: Treatment of lung adenocarcinoma cell lines with cisplatin, cytarabine, doxorubicin, gemcitabine, vinorelbine or pemetrexed activate the PERK branch of the UPR which, in turn, induces EMT through the upregulation of SNAI1 and ZEB1 gene expression as well as EMT-like changes in several tissues in mice [59] (Figure 3).