Interestingly, the authors emphasize that not all somatic mutations are equally present in every cancer type but rather it appears to be some preferences, with IRE1 mutations being predominant in cancers from the nervous system, whereas gastrointestinal cancers are enriched in ATF6 and IRE1 mutations and urologic and lung cancers in ATF6 and PERK mutations. Here, ERN1 is linked to cancer.