EDN1 and preeclampsia: However, in the circulatory system of women with advanced preeclampsia, the presence of markers released by activated or damaged endothelium (markers of oxidative stress, von Willebrand factor, thrombomodulin, endothelin-1, fibronectin, and inflammatory cytokines, among others) and deficiency of vasodilators (prostacyclin and nitric oxide) have been demonstrated [13].