Paradoxical to the upregulation of KCNE1 in uterine cancer cell lines, KCNE1 overexpression in an astroglioma cell line (U87-MG) induces apoptosis and KCNE1 is one of the four genes deleted in the 21q22.12 microdeletion which causes a predisposition to acute myelogenous leukaemia [160,161]. Here, KCNE1 is linked to acute myeloid leukemia.