This, in turn, leads to cell cycle progression and cellular proliferation.[1,8,9] In addition, nuclear translocation of PKM2 is required for PKM2 autoregulation as well as glycolytic gene expression, to promote EGFR-dependent Warburg Effect and tumorigenesis.[10] Despite these findings on PKM2’s function as a protein kinase, identification of specific mediators between PKM2 and cancer invasion has remained elusive. The gene discussed is PKM; the disease is cancer.