PKM and cancer: An important step in MMP regulation is transcription: ETS-1 has been reported to be overexpressed in a variety of human cancers and plays a major role in transactivation of several protease genes involved in matrix degradation such as MMP-1, MMP-2, and MMP-9.[24] Capable of enhancing the invasive potential of cancer cells both in vitro and in vivo,[25] ETS-1 posed itself as a potent mediator that might bridge upregulated PKM2 and enhanced invasion in IHOK-P.