Given the involvement of increased TGFβ ligand in Marfan syndrome, it is not surprising to find that mutations in other components of the TGFβ pathway can result in related disorders, collectively termed MFS-like syndromes [3–5], including Marfan syndrome 2 (MFS2), Loeys-Dietz syndrome (LDS), Ehlers-Danlos syndrome (LDS-2), Thoracic Aortic Aneurysms and Dissections (TAAD) and Shprintzen-Goldberg syndrome (SGS). Here, TGFB1 is linked to Goldberg-Shprintzen syndrome.