UQCC2 and prion disease: Five of six (5/6) mice inoculated with 10−4 CWD+ cervid brain CBP6 (average clinical disease 232 DPI, range 181 to 257), three of five (3/5) mice inoculated with 10−5 (average clinical disease 332 DPI, range 231 to 502) and 2/5 mice inoculated with 10−6 (average clinical disease 426 DPI, range 286 to 502) CWD+ cervid brain CBP6 showed signs consistent with prion disease and demonstrated PrPSc deposition by IHC and WB (Fig 4, Table 2, S1 and S2 Figs).