The increase in obesity showed a direct effect on IL-6 (males 0.36, 95% CI 0.28, 0.43; females 0.58, 95% CI 0.51, 0.64) and CRP (males 0.76, 95% CI 0.62, 0.90; females 1.00, 95% CI 0.86, 1.13) and an inverse relationship with adiponectin in females (-2.43 95% CI -4.37, -0.50). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.