In a clinical trial of healthy women from the USA, the authors found increased circulating levels of IL-6 and CRP with an increasing number of clinical cardiovascular risk factors (age > 60 year, current smoking, sedentary lifestyle, BMI > 27, systolic blood pressure ≥ 140 mmHg and diabetes); this was the only study found in the literature assessing the additive effects of several risk factors and IL-6 and CRP. This evidence concerns the gene CRP and diabetes mellitus.