There was a positive association for IL-6 and CRP in both sexes according to obesity (in the adjusted analysis); women who were obese in ≥ 2 follow-ups were associated with a mean IL-6 of 2.45 and a CRP of 3.74 compared to IL-6 of 1.21 and CRP of 1.29 for those with no exposures (adjusted analysis) (Table 3). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.