ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The magnitude of the effect points out that obesity being present at two or more of the follow-up visits is associated with 48.7% and 110% of increase in IL-6 and CRP, respectively, and a decrease of 11% in adiponectin, in males; higher magnitude is observed among females, with 102% and 189% of increase in IL-6 and CRP, respectively, and a decrease of 23% in adiponectin (findings from the adjusted linear regression in Tables 2 and 3).