IL6 and obesity due to melanocortin 4 receptor deficiency: While the mechanisms that lead to increased values of these inflammatory markers are not completely understood, some risk factors, such as smoking, obesity and others, may be involved in the regulation of pro-inflammatory cytokines [3]; although circulating levels of IL-6 and CRP are physiologically linked, it remains unclear whether these markers track with one another with respect to several risk factors in healthy subjects.