CRP and obesity due to melanocortin 4 receptor deficiency: In the 1982 Pelotas Birth Cohort carried out in the same city in Brazil as the present 1993 Cohort, the authors assessed the association between CRP and obesity, smoking and alcohol, among other variables in a cross-sectional approach; a direct association was found between CRP and obesity, smoking (only in males), and no association with alcohol consumption [42].