Although the number of TCRαβ+CD8αα+ IELs was reduced in Rbpj−/− mice, the Rbpj−/− and Rbpj+/+ mice showed comparable body weight loss after induction of colitis by dextran sodium sulfate (DSS) or 2,4,6-Trinitrobenzene sulfonic acid (TNBS) (S2 Fig). Here, RBPJ is linked to colitis.