INS and heart disorder: Perhaps the most interesting observation from the efficiency analysis comes from the bottom of Fig 6B where one can see increased positive scores for adalimumab, etanercept and, to a lesser extent, certolizumab pegol for a number of functions related to heart disease as well as two metabolic signaling pathways (Adipocytokine and Insulin signaling), for which infliximab shows lower efficiency at both stages of intervention.