In this work, we present a computational analysis [18–24] based on a standardized and highly robust protocol involving the administration of four different anti-TNF agents in the hTNFTg (Tg197) humanized mouse model of RA, that has been essential in proving the central role of TNF in the arthritis pathology and its validity as a major therapeutic target [12]. This evidence concerns the gene TNF and arthritic joint disease.