TP53 and cancer: For example, although a question such as ‘What is the rate of TP53 mutations in cancers?’ is a question that some of these tools can be used to answer, a question such as ‘Which pathways do TP53 mutations suppress and activate in different cancers, and how do they contribute to the poor outcome?’ is a question that cannot be answered, or even formulated, using any of the existent tools.