NFKB1 and cancer: In addition, studies have shown that anti-inflammatory drugs have a positive effect on cognitive function in mice treated with lipopolysaccharide and scopolamine (Jain et al. 2002) Cyanidin-3 glucoside, one of the most abundant anthocyanin in E. amoenum extract reduces the production of inflammatory agents such as prostaglandin E2, and COX-2 in cancer cells by inhibiting the activation of the transcription factor C-jun and NF-κB (Munoz-Espada and Watkins 2006).