However, differences between control versus conjunctivitis eyes were not statistically significant, and were fairly minimal (up to 64% increase) when compared to plasma albumin (up to 12,000%).11 Unlike albumin, a very large molecule (66,500 Da) that does not permeate through intact conjunctival tissue,24 we suspect that smaller molecules like prednisone (358 Da) and prednisolone (360 Da) readily cross the blood–tear barrier under normal conditions, and are therefore not significantly impacted by conjunctival inflammation. Here, ALB is linked to conjunctivitis.