In previous studies, occurrence of LEPR mutation in a cohort of 39 children of consanguineous origin was reported to be 3% (Saeed et al., 2014), compared to the occurrence of LEPR mutation in four consanguineous families with severe obesity at 50% (Gill et al., 2014). This evidence concerns the gene LEPR and obesity due to melanocortin 4 receptor deficiency.