CD4 and cancer: Serum albumin is produced mainly by hepatocytes and the albumin synthesis is regulated by several proinflammatory cytokines, which are produced by the host, tumor microenvironment and cancer cells, and may play crucial roles in carcinogenesis, cancer progression, and angiogenesis.39 The serum albumin level is correlated with an increased inflammatory response to the tumor.39 Lymphocyte cell subpopulations include CD4+ and CD8+ T‐cells, NK cells, NKT cells, gamma‐delta T‐cells, and B‐cells, which are closely related with tumor immunity.