LEF1 and neoplasm: Several downregulated genes were shown to have a strong protein interaction, but most of these genes, such as Fgfr2, Tnc, and Lef1, have been positively associated with tumor progression (Katoh and Nakagama, 2013; Murakami et al., 2001; Shao et al., 2015), suggesting their downregulation is not involved in 4C11+ cells aggressive phenotype.