Of particular interest is how cancer cells respond to laminin-rich vs. collagen-rich microenvironments: for example, during cancer development and progression, the epithelium is remodeled, undergoing degradation followed by deposition and crosslinking of collagens and transitioning from a soft, laminin-rich matrix to a stiff, collagen-rich matrix that influences the maladaptive activities of cancer cell.4 Here, LAMB2 is linked to cancer.