For the AngII AAA cohort, Col8a1 was significantly upregulated relative to the Saline cohort and was functionally classified (i.e., shared multiple annotation terms in common) with genes encoding for complement pathway factors C1q43 and C1qtnf644 as well as Emilin2 (elastin microfibril interfacer 2).45 The gene discussed is COL8A1; the disease is triple-A syndrome.