Based on the finding of high circulating levels of MMP-9 in patients with acute aortic dissection, Kurihara et al. determined that AngII induced the release of MMP-9 from neutrophils, which led to acute aortic dissection in the thoracic aorta of mice that were administered a lysyl oxidase inhibitor.39 The gene discussed is LOX; the disease is Aortic dissection.