Finally, similar to theprognostic ability of GRHL2, OVOL, and ΔNP63α25,58,72—factors that can stabilize ahybrid E/M phenotype25,36,53,55—higher levels of ESRP1 have beenassociated with (a) poor OS in breast cancer, (b) poor 5-year progression-freesurvival (PFS) and OS in epithelial ovarian cancer samples,77,78 (c) poor prognosis of distant metastasisin breast cancer samples,79 and(d) enhanced metastasis in colorectal cancer progression.80 Here, GRHL2 is linked to colorectal cancer.