ZEB1correlates negatively with ESRP1 and positively with HAS2 in NCI-60 and CCLE cellline cohorts and in lung, breast, and pancreatic tumors,38,39 indicating that feedback loops operatingamong ZEB1, ESRP1, and HAS2 may modulate cancer cell plasticity across subtypes. This evidence concerns the gene HAS2 and cancer.