This reverse trend was also observed in another study where primarytumor cells were isolated from KPC mice (a well-studied pancreatic cancer mousemodel driven by Pdx1-Cre-mediated activation of mutant Kras and p53) and KPCZmice (KPC mice with ZEB1 knockout)50 [Fig. 3(a), iii;GSE87472]. This evidence concerns the gene KRAS and familial pancreatic carcinoma.