Work on breast cancer has shown shear stress to affect: adherence to theendothelium58 due to anincrease in the expression of EMT characteristics,51 acidic microenvironment development,59 cancer stem cellpopulations,60migration,61,62involvement of caveolin-1 through the FAK/Src, ROCK/pMLC,52 and PI3K/Akt/mTOR63 pathways, and glycoprotein IIb/IIIa andαvβ3 integrin in PI3K/Akt and NF-kB signaling.64 The gene discussed is PIK3CA; the disease is breast carcinoma.