The TCGA project provided much more dimensional data, including gene expression, genotype, epigenetics, and somatic alterations as well as the proteome, that constitute a precious resource for research on the biological mechanism of lung cancer.52,53 With these public resources, several candidate susceptibility genes, including RNASET2 in 6q27, NRG1 in 8p12, AMICA1 in 11q23.3, and SECISBP2L in 15q21.1, have been identified through functional annotation. This evidence concerns the gene RNASET2 and lung carcinoma.