In 2008, three independent studies simultaneously reported chromosome 15q25.1 as a susceptibility region for lung cancer in Caucasian populations; in this region, rs8034191 and rs1051730 were the major tagging variants.29–31 The region harbors six protein-coding genes, including three genes, CHRNA3, CHRNB4, and CHRNA5, that encode nicotinic acetylcholine receptors. This evidence concerns the gene CHRNA3 and lung cancer.