Adenocarcinoma (AC) and squamous cell carcinoma (SqCC) are two major histological subtypes of lung cancer.16 Obvious heterogeneity has been observed among different histological subtypes of lung cancer; for example, 3q28 (TP63) and 5p15 (TERT-CLPTM1L) were more prominent among AC,17,18 and 12q23.1 (SLC17A8-NR1H4) was significantly associated only with SqCC. The gene discussed is NR1H4; the disease is lung cancer.