SMAD2 and cancer: Based on the observation of upregulated EMT (Supplementary Fig. S3) and associated key signature genes such as TGFB2, TGFBR2, SMAD2, and ZEB1 (Fig. 4a) in the high-risk patients, we infer that m6A regulatory machinery must interact with EMT to regulate cancer metastasis in various human malignancies.