Interestingly, among all the seven m6A regulators studied, WTAP, METTL3, FTO, and ALKBH5 were all significantly upregulated in the high-risk group vis-à-vis low and intermediate groups (Fig. 4a, P < 0.001, Student’s t tests), while YTHDF1, YTHDF2, and METTL14 were all significantly downregulated in the high-risk group in the CRC Meta-validation cohort (Fig. 4a, P < 0.001, Student’s t tests). This evidence concerns the gene FTO and colorectal carcinoma.