While HSV-1 TK converts ganciclovir into phospho-ganciclovir, a toxic compound to dividing glioma cells, Flt3L differentiates precursors into dendritic cells and acts as a chemokine for dendritic cells resulting into killing of glioma cells and release of tumor antigens in the tumor microenvironment. The gene discussed is FLT3LG; the disease is glioma.