Although IL-4 has been linked with pro-tumor properties,34–36 mice overexpressing IL-4 showed significant tumor growth reduction compared to non-transgenic mice,37 and there are reports of inverse correlations between allergic conditions and the risk of developing certain types of cancer including ovarian cancer.38–40 Here, the positive prognostic association of IL-4 and some Th2 signatures may suggest potential anti-tumor functions in ovarian carcinomas. This evidence concerns the gene IL4 and cancer.