TGFB1 and hepatocellular carcinoma: These characteristics include the upregulation of proteins with unfavorable prognostic influence (TGFβ1, KRT19, and MMP9), activation of pathways associated with disease progression (HIF1, integrin and Rho GTPases pathways), and enrichment of established transcriptomic signatures of aggressive HCC subclasses that were specifically found in the S-III subtype.