To determine if spinal cord-derived cultures respond appropriately to a classical PAMP, we challenged them with bacterial lipopolysaccharide (LPS) and compared their response to that induced by myelin debris; sterile clearance of which is essential to promote lesion repair in demyelinating diseases such as MS and experimental models (Kotteret al., 2005;Napoli & Neumann, 2009;Neumannet al., 2009) in a CX3CR1-and TREM2-dependent manner (Cantoniet al., 2015;Lampronet al., 2015;Polianiet al., 2015). Here, TREM2 is linked to myeloid sarcoma.