MKI67 and neoplasm: Other prognostic factor predicting how aggressive the disease course will be were reported too: high mitotic rate of > 20 per 10 high-power fields (HPF), lesions greater than 5cm, tumor necrosis of > 50%, vascular invasion, increased tumor depth with fascial involvement, high stage, increased DNA ploidy, high Ki-67 proliferative index and acral distribution [5, 6].