TARDBP and amyotrophic lateral sclerosis: Using a mouse model of TDP-43 proteinopathies that conditionally overexpresses the wild-type human TDP-43 protein (hTDP-43-WT) in forebrain neurons and reproduces neuropathological changes of the FTD/ALS spectrum (Igaz et al., 2011), we have recently shown that they display early behavioral phenotypes in the cognitive and social domains (Alfieri et al., 2016).