TARDBP and proteostasis deficiencies: These diseases may represent a single pathological entity with diverse clinical manifestations (Geser et al., 2010; Burrell et al., 2016), included within the heterogeneous group of “TDP-43 proteinopathies.” TDP-43 pathology frequently associates with other disorders, including Alzheimer’s disease, dementia with Lewy body, hippocampal sclerosis, and chronic traumatic encephalopathy, among others (Kovacs, 2016).