Third it has been established that inflammatory monocyte/macrophages egress from the bone marrow and into the peripheral blood during CMV infection in a C-C motif chemokine receptor (CCR)2-depedent manner (32), further supporting investigation of the mechanism for CMV in the immunopathology of AOSD by activating neutrophils and macrophages. The gene discussed is CCR2; the disease is cytomegalovirus infection.