Immediately ex vivo, atypical MBCs in malaria-exposed individuals have high basal levels of phosphorylated kinases in the B cell receptor for antigen (BCR) signaling pathway as compared to conventional MBCs and upon BCR crosslinking in vitro the fold change in phosphoproteins in atypical MBCs is less than that of conventional MBCs (2, 6). Here, BCR is linked to malaria.