CAFs express the catabolic enzyme indoleamine 2,3-dioxygenase (IDO) and release a variety of factors such as transforming growth factor- β (TGF- β), vascular endothelial growth factor (VEGF), interleukins (IL)-6, IL-1 and IL-8, and prostaglandin E2 (PGE2) that directly or indirectly participate in the development of an immunosuppressive tumor milieu that promote tumor growth, angiogenesis and metastasis (10). This evidence concerns the gene VEGFA and neoplasm.