Recently, Homayouni et al. (118) observed that 500 mg/day of hesperidin supplementation in T2DM patients was related to anti-inflammatory effects in the short term (IL-6, TNF-α, hs-CRP reductions, P < 0.05) as well as a significant increase in the total antioxidant capacity in serum (13.4% ± 19.2) and a reduction in mean arterial BP of 2.5% ± 4.6. Here, TNF is linked to type 2 diabetes mellitus.