Another meta-analysis of 19 RCTs on cocoa flavan-3-ols found significant effects on inflammation and oxidative stress biomarkers: CRP (WMD: −0.83 mg/dL, 95% CI: −0.88, −0.77), VCAM-1 (WMD: 85.6 mg/mL, 95% CI: 16.0, 155), lipid metabolism (TG, HDL-C), and insulin resistance modulation (fasting insulin, HOMA-IR, QUICKI, quantitative insulin sensitivity check index, and the insulin sensitivity index, ISI) (307). The gene discussed is INS; the disease is Insulin resistance.