In another study, patients with stable CAD were randomized into 3 groups: (A) folic acid plus vitamin B12 and B6, (B) folic acid plus vitamin B12, and (C) vitamin B6 alone, and it was found that vitamin B did not affect the levels of pro-inflammatory markers (soluble CD40 ligand, sCD40L, IL-6, CRP, and neopterin) related to atherosclerosis (55). The gene discussed is CD40LG; the disease is atherosclerosis.