Among them, several previously reported genes were identified, which have previously been demonstrated to participate in the pathogenesis of pSS, including IRF1, CXCL9 (IFN-gamma), CXCL10, MS4A1(CD20) (24), IGHG4 (25), CXCL13 (26, 27), TAP1 (28, 29), CD52 (30), PSMB8-AS1 (29), FPR3 (30), PSMB9 (31), and GBP1 (32, 33), and some previously unreported DEGs like IGLV3-19, IGHV1-18, IGHV4-39, TLR10, and TYMP. Here, IRF1 is linked to peeling skin syndrome.