ADO and Miyoshi myopathy: The high levels of ADO measured in the culture supernatants of primary melanoma cells and the BM plasma from MM patients (12) were also detected by metabolomic screening using AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide)-treated malignant cells identifying pyrimidine starvation as the mechanism of AICAR-induced apoptosis in mPCs (77).