Results of a recent study in MM patients, evaluated according to the International Staging System (ISS) (56, 57), revealed that ADO levels in BM plasma samples at diagnosis were higher in patients at an advanced stage (ISS = III) with symptomatic MM than in those at the earlier MGUS/SMM stages (pooled ISS = I-II) (12). The gene discussed is ADO; the disease is Miyoshi myopathy.