CD8A and infection: Certainly, many studies have demonstrated mechanisms used by cells to defend themselves against the proliferation of T. gondii such as stimulation of CD8+ T cells to secrete specific cytokines in the brain (Harris et al., 2012), the production of ROS (oxygen species) (Kim et al., 2017), and the elevated level of FasL in the supernatants of infected HTR8/SVneo cells and macrophages, preventing the spread of infection (Guirelli et al., 2015).