Remarkably, SDI-H mice had increased infarct volumes after ischemic lesions (Figure 2C) in the MCAO stroke model and exacerbated neurological functional impairment (Figure 2D), with increased pro-inflammatory (IL-17+) γδ T cells and reduced (CD4+CD25+) T cells in the spleen (Supplementary Figures 1B,C). This evidence concerns the gene CD4 and stroke disorder.