In a piglet model of hypoxic-ischemic encephalopathy at term, canonical suppression of Glt-1 in astrocytes of the striatum and hippocampus was accompanied by upregulation in neurons of the striatum (Martin et al., 1997b; Danbolt, 2001; Pow et al., 2004; Desilva et al., 2007, 2012). The gene discussed is SLC1A2; the disease is perinatal asphyxia.