Guanosine enhances EAAT2 transport function and has shown neuroprotective effects in rat models of hypoxic-ischemic encephalopathy (Moretto et al., 2005, 2009) and adult cortical focal ischemia, via multiple mechanisms including prevention of free radical attack and pro-inflammatory response (Hansel et al., 2014, 2015). This evidence concerns the gene SLC1A2 and perinatal asphyxia.