A previous study reported that FOXO1 antagonizes endothelial c-Myc signaling (Wilhelm et al., 2016), and because c-Myc is a powerful driver of glycolysis, mitochondrial metabolism, and growth, we hypothesized that RES induce FOXO1 inactivation by activating SIRT1, to restore hyperglycemia-triggered endothelial dysfunction and disturbance of angiogenesis, followed by the promotion of diabetic wound healing in a c-Myc-dependent manner. Here, FOXO1 is linked to Hyperglycemia.