Consistent with elevated levels of pro-inflammation cytokines and exacerbated fibrosis, MCD-diet feeding resulted in severe liver damage as indicated by the elevated plasma level of liver enzymes, particularly ALT, which has been considered as a requisite in the diagnosis of NASH (Torres and Harrison, 2013; Diehl and Day, 2017). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.