P53 pathway regulates DNA repair and apoptosis in HCT116 cells (Li et al., 2015), and there is growing evidence for the involvement of olfactory receptor pathway in cancers of non-olfactory tissues such as prostate (Neuhaus et al., 2009), lung (Giandomenico et al., 2013; Kalbe et al., 2017), and colon cancers (Morita et al., 2016). The gene discussed is TP53; the disease is malignant colon neoplasm.