Further, the expression level of DNMT3A and DNMT3B have been associated with sensitivity to decitabine cytotoxic response in embryonic cells (Oka et al., 2005), testicular germ cell tumor (Beyrouthy et al., 2009) and have also shown to be predictive of decitabine treatment response in patient-derived xenograft model for triple negative breast cancer (Yu et al., 2018). Here, DNMT3A is linked to testicular germ cell tumor.